Aniracetam is a lipophilic derivative of Piracetam, exhibiting many of the same same effects with an estimated 3-6x increased potency. It increases cholinergic neurotransmission as is typical of the Racetam class of nootropics.
It also positively modulates glutamatergic activity via AMPA receptors and is considered the model for Ampakine agents.
Additional mechanisms of action involve Dopaminergic, Serotonergic and GABAergic pathways.
Like Piracetam, Aniracetam is hypothesized to facilitate cholinergic transmission. Unlike Piracetam, Aniracetam is fat-soluble which may contribute to its increased potency.
Aniracetam was found to improve cognitive function in elderly patients diagnosed with mild to moderate impairments caused by senile dementia of the Alzheimer type (SDAT).
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