Alpha-glycerophosphocholine or sometimes just glycerophosphocholine (Alpha GPC) is a Choline-containing supplement that, appears to be pharmacologically active at higher doses.
Alpha GPC is mostly marketed due to it conferring dietary choline to the body following oral ingestion, and being the most efficient choline prodrug at doing so (able to influence both systemic and brain concentrations of choline).
Alpha GPC also appears to support the structure of cellular membranes, which is not a common mechanism attributed to choline prodrugs (only CDP-choline is associated with lipid membranes in this sense).
Oral supplementation of alpha GPC is of interest for nootropic purposes, as it appears to have cognitive-enhancing properties and attenuate the rate of cognitive decline in the elderly.
In regards to reducing the rate of cognitive decline, alpha GPC at high doses (1,200 mg) does appear to be somewhat effective in mild to moderate Alzheimer's disease and works nicely with the standard therapy.
Athletes are at times interested in alpha GPC due to its ability to enhance growth hormone production and to enhance power output, which has a lone pilot study in support of 600 mg alpha GPC prior to exercise.
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