Generally, compounds or supplements that promote lifespan and promote a youthful phenotype are both referred to as anti-aging supplements.
The known anti-aging supplements under the category Youthful phenotype supplements are those that 'add life to your years', and they are plenty.
The list/stack of supplements below shows the most promising, commonly used, and well-researched supplements for anti-aging.
Take 100 mg thrice a day. This dosage is implicated in reducing stress and improving cognition especially in the elderly.
Resveratrol does not appear to actually extend life, although it may extend the median survival time of research animals by reducing the onset of cardiac death.
Preserves a youthful phenotype in regards to circulatory health, and at low doses can promote blood flow and possibly benefit insulin resistance. Higher doses may improve cerebral blood flow and possibly cognition, although the latter claim is not fully studied.
3) Pyrroloquinoline quinone
Claimed to increase longevity and improve a youthful phenotype through proliferating mitochondria, the cellular energy house. Implicated in increasing cognition and well being in the elderly.
Acetyl-L-Carnitine, appears to be elevated to vitamin-like status when in deficiency states. One of the deficiency states appears to be aging, where the normally defunct claims of 'burning fat and building muscle' may actually be relevant, unlike youth where it is ineffective.
L-Carnitine, GPLC, and LCLT are all acceptable; commonly used with Alpha-Lipoic Acid.
This herb itself and its active saponin seem to be able to promote a youthful phenotype in older animals, but has not yet been shown to extend lifespan.
The acute usage is of up to 1-1.5 g daily (in 4-6 divided doses) (250 mg is the maintenance dose) used therapeutically for 1-2 weeks.
Centrophenoxine implicated in aiding cognition/memory in the elderly, especially those with some genetic susceptibility or family relations to Alzheimer's Disease.
7) Vitamin D
2000 IU Vitamin D appears to be the lower end of what is recommended or otherwise seen to improve median lifespan secondary to reduced mortality. This is most likely related to reducing falls in the eldery, but is still a form of 'life extension' and one of the only ones in this list shown to be related to improved functionality in the elderly.
8) Alpha Lipoic Acid
Commonly used with Acetyl-L-Carnitine, ALA is a fatty acid which serves as a anti/pro oxidant and may help regulate oxidative stress. Also linked to acting similar to leptin, suppressing appetite and stimulating glucose uptake into fat and muscle tissue.
Claimed to increase lifespan, with mixed results in mice. ALA seems to be capable of adding life to years, however, especially secondary to weight loss that may come from ALA (appetite suppression, at least in animals).
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