There is often confusion among nutritional supplements users when it comes to speaking of yohimbe and yohimbine. There are 2 kinds on the market - yohimbine hydrochloride (Yohimbine HCL) and yohimbe bark.

Both are used in medicine and among sports enthusiasts. In this article, however, we will not discuss their properties. We will focus on the differences between the two types. Yohimbine is a substance, which is contained in the bark of some African and Asian trees.

Yohimbine has become one of the most effective, if not the most effective, supplements for fat burning. Yohimbine is known as an aphrodisiac, stimulant, energy agent, but there is little information about its interaction with human hormones.

One such interaction may be essential for yohimbine effectiveness as a nutritional supplement. Therefore, in the following lines, we will talk about what science says about the relationship between yohimbine and insulin.

Insulin is a peptide hormone, which is secreted by the pancreas in order to regulate the metabolism of carbohydrates and fats. It improves the absorption of blood glucose by the skeletal muscles and fat tissues.

Yohimbine, as an individual extracted alkaloid, can be most commonly found as hydrochloride (Yohimbine HCL). Practically speaking, yohimbine and yohimbine hydrochloride is the same thing. The Yohimbine HCL form is just more stable, soluble and absorbable and is often used in pharmaceuticals.

The first advantage of yohimbine is the fact that most people feel little side effects. Yohimbe has been used for years and beyond clinical practice by some African tribes as an aphrodisiac, as a hallucinogen, and in cases with impotence problems.

Basically, Yohimbe bark and yohimbine HCL both products share common properties, but when it comes to erectile dysfunction - the yohimbe bark is considered the more effective option.

Top 10 Yohimbine Brands Reviewed

Yohimbine HCL

by Primaforce

PrimaForce Yohimbine HCl, 2.5mg Capsules - Weight Loss Supplement - Supports Fat Loss, Boosts Metabolism, 270 Count (Pack of 1)

Primaforce Yohimbine HCL Overview

  • Tested for purity and potency;
  • Supports fat loss;
  • Promotes appetite control;
  • Maximize sex drive;
  • Product produced in a GMP certified facility.

What Is Yohimbine Used For

For many years yohimbine supplements have been and still continues to be one of the most popular supplements for men and women. Its popularity is because it is used as a strong aphrodisiac and powerful problem areas fat burner.

Recent research proves that yohimbine has some anti-oxidant properties and also helps the proper functioning of the heart. As a fat-burning agent, it can be perfectly combined with synephrine and caffeine.

Dosage

Take 1-3 capsules per day, preferably one of the capsules prior to a workout. If you have caffeine or other stimulants intolerance, please take into account that the product contains large quantities of such substances.

Possible Side Effects

Possible side effects might include anxiety, insomnia, euphoria, diarrhea, rapid urination, rapid heartbeat, increased blood pressure, etc. The strength of side effects depends on both the dose and the sensitivity of the person taking yohimbine.

Suggested Use and Tips

Consume yohimbine capsules in divided doses, prior to meals. On training days, consume one serving prior to exercise. Start at one (1) capsule to assess tolerance.

Natrol Yohimbe Bark Overview

Natrol® Yohimbe Bark is produced from the bark of the evergreen African wood Pausinystalia johimbe. Natrol® provides all the benefits of this venerable herb. 

The Yohimbe is a supplement that will help you enjoy a longer life of youth. This product combines the functional benefits of the whole plant and therefore it is not standardized in terms of specific active substances. 

It is also claimed to promote sexual health and vitality. If you are taking any medications ( including MAOIs), consult a qualified doctor before using this product.

What Is Yohimbe Used For

For many years yohimbine supplements have been and still continues to be one of the most popular supplements for men and women. Its popularity is because it is used as a strong aphrodisiac and powerful problem areas fat burner.

Recent research proves that yohimbine has some anti-oxidant properties and also helps the proper functioning of the heart. As a fat-burning agent, it can be perfectly combined with synephrine and caffeine.

Dosage

Take 1 capsule, up to three times daily, with a meal. Do not exceed the recommended dose.

If you have caffeine or other stimulants intolerance, please take into account that the product contains large quantities of such substances.

Possible Side Effects

Possible side effects might include anxiety, insomnia, euphoria, diarrhea, rapid urination, rapid heartbeat, increased blood pressure, etc. 

The strength of side effects depends on both the dose and the sensitivity of the person taking yohimbine.

Suggested Use and Tips

Consume Natrol yohimbe bark capsules in divided doses, prior to meals. On training days, consume one serving prior to exercise. Start at one (1) capsule to assess tolerance.

ALLMAX Nutrition Yohimbine Overview

  • α2 adrenoreceptor antagonist;
  • Supports fat-burning;
  • Suppresses appetite;
  • Supports sexual performance;
  • 100% quality & potency guaranteed.

What Is Yohimbe Used For

For many years yohimbine supplements have been and still continues to be one of the most popular supplements for men and women. Its popularity is because it is used as a strong aphrodisiac and powerful problem areas fat burner.

Recent research proves that yohimbine has some anti-oxidant properties and also helps the proper functioning of the heart. As a fat-burning agent, it can be perfectly combined with synephrine and caffeine.

How Does This Product Work

ALLMAX Yohimbine + Rauwolscine (Alpha-Yohimbine) are the pure synthetic versions of Pausinystalia Yohimbe and Rauwolfia serpentina; thousands of times more powerful than the original herbal extracts from which they were isolated.

Yohimbine + Rauwolscine effectively shuts down fat storage and increases lipolysis (the release of fatty acids within stored fat).

Dosage

Take 1 capsule daily just prior to exercise. Do not exceed 2 capsules daily. If you have caffeine or other stimulants intolerance, please take into account that the product contains large quantities of such substances.

Possible Side Effects

Possible side effects might include anxiety, insomnia, euphoria, diarrhea, rapid urination, rapid heartbeat, increased blood pressure, etc. The strength of side effects depends on both the dose and the sensitivity of the person taking yohimbine.

Suggested Use and Tips

Consume ALLMAX Yohimbine capsules in divided doses, prior to meals. On training days, consume one serving prior to exercise. Start at one (1) capsule to assess tolerance.

Yohimbe-Plus

by Irwin Naturals

Irwin Naturals Yohimbe-Plus Maximum Enhancement for Men, Boost Vitality 100-Liquid Softgels Bundle with a Lumintrail Pill Case

Irwin Naturals Yohimbe-Plus Overview

  • Libido support;
  • 2% standardized Yohimbine;
  • Yohimbe bark extract;
  • Maximum energy;
  • Fast-acting formula;
  • Promotes stamina through increased blood flow;
  • Supports healthy sexual function;
  • Standardized for purity and potency.

What Is Yohimbine Used For

For many years yohimbine supplements have been and still continues to be one of the most popular supplements for men and women. Its popularity is because it is used as a strong aphrodisiac and powerful problem areas fat burner.

Recent research proves that yohimbine has some anti-oxidant properties and also helps the proper functioning of the heart. As a fat-burning agent, it can be perfectly combined with synephrine and caffeine.

Dosage

Take 1-3 capsules per day, preferably one of the capsules prior to a workout.

If you have caffeine or other stimulants intolerance, please take into account that the product contains large quantities of such substances.

Possible Side Effects

Possible side effects might include anxiety, insomnia, euphoria, diarrhea, rapid urination, rapid heartbeat, increased blood pressure, etc. The strength of side effects depends on both the dose and the sensitivity of the person taking yohimbine.

Suggested Use and Tips

Take 1 capsule twice daily. Do not exceed 2 capsules daily. Begin use with half the recommended serving (1 capsule daily) to assess tolerance.

What Is Yohimbine Used For

For many years yohimbine has been and still continues to be one of the most popular supplements for men and women. Its popularity is because it is used as a strong aphrodisiac and powerful problem areas fat burner.

Recent research proves that yohimbine supplements have some antioxidant properties and also helps the proper functioning of the heart. As a fat-burning agent, it can be perfectly combined with synephrine and caffeine.

Possible Side Effects

Possible side effects might include anxiety, insomnia, euphoria, diarrhea, rapid urination, rapid heartbeat, increased blood pressure, etc. The strength of side effects depends on both the dose and the sensitivity of the person taking yohimbine.

Suggested Use and Tips

Shake well before using. Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 1 to 3 times per day. Best taken between meals.

What Is Yohimbe Bark

As the name suggests, products that contain yohimbe bark may have it in the form of powder from bark of crushed branches and trunks, or in the form of yohimbe extract. The extract is a common option.

Unlike hydrochloride (HCL), the bark contains much more alkaloids, including the yohimbine alkaloid, which is considered the most potent and effective one. The concentration of all alkaloids in the bark is about 6%, as 10-15% of that content is yohimbine.

Yohimbe has been used for years and beyond clinical practice by some African tribes as an aphrodisiac, as a hallucinogen, and in cases with impotence problems. Basically, both products share common properties, but when it comes to erectile dysfunction- the yohimbe bark is considered the more effective option.

Yohimbe contains the corynanthine alkaloid, which is the alpha-1 adrenoceptors blocker. In contrast, Yohimbine is just the alpha-2 adrenoceptors blocker. 

While the individual blocking of both alpha-adrenoceptors might affect erection, it is believed that the alpha-1 adrenoceptors are more powerful and the best overall effect of their blocking can be actually achieved by the yohimbe bark. There are some problems, however, in the bark of yohimbe. 

Although this problem varies in different people, most people, that have taken yohimbe bark, complain from severe side effects such as increased heart rate and blood pressure, sweating, erythema, skin rash, nausea, fatigue, and others.

Yohimbine has the same side effects, but fewer people have a problem with it. The problem with the bark is supposed to be due to other alkaloids therein. Another problem arises from the fact that concentrations of alkaloids vary greatly including yohimbine.

If the product is made of the crushed tree roots - its power depends on how old that tree is, as the concentrations of alkaloids increase over time. If the product is an extract, its power depends on the method of extraction, but it is believed that it cannot contain more than 6-7%of the total alkaloids.

An earlier study from 1995 showed that the vast majority of products on the market of yohimbe extract contained very low concentrations of alkaloids. Yohimbine was almost absent. 

Whether that is true –we don’t know even today. But if you buy bark extract, at least read the label in order to see if this is standardized yohimbine and what is the percentage therein.

What Is Yohimbine

Yohimbine, as an individual extracted alkaloid, can be most commonly found as hydrochloride (Yohimbine HCL). Practically speaking, yohimbine and yohimbine hydrochloride is the same thing. 

The Yohimbine HCL form is just more stable, soluble and absorbable and is often used in pharmaceuticals. As mentioned above, many years ago some African tribes used the tree and its bark. 

With the progress of science, however, people found that the main effect of the tree is due to its alkaloid - yohimbine. In general, all researches on the effectiveness were carried out with the yohimbine alkaloid, not the bark extract.

The first advantage of yohimbine is the fact that most people feel little side effects. Second, since it is sold in a dosage of up to 3.5 mg in a capsule, the dosage is more flexible and more easily adapted according to the tolerance of the recipient.

Last but not least, yohimbine is considered the most potent alkaloid and is a strong alpha-2-adrenoceptors blocker, because that is a popular supplement among people that want to reduce body weight and body fat.

Yohimbine and Its Intake on an Empty Stomach

Have you ever wondered why people recommend thermogenic fat burners, Yohimbine HCl, in particular, to be taken on an empty stomach? This is not just a gimmick, but an approach that is essential to the effectiveness of many thermogenic supplements.

Studies on humans have shown that Yohimbine HCl, taken on an empty stomach, enhances the lipolysis and does not affect the blood sugar levels and insulin secretion. 

This has been confirmed in other studies and the conclusion is that the intake on an empty stomach provides maximum efficiency of yohimbine as a fat burner. On the other hand, the biomarkers for fat loss (increased glycerol and NEFA) decrease drastically if yohimbine is combined with a diet rich in proteins and carbohydrates.

This is partly explained by the fact that yohimbine has a synergistic effect with physical exercises in terms of lipolysis, as the intake of nutrients during exercise blocks the fat burning processes.

How Does Insulin Secretion Affect Yohimbine

Insulin alone does not directly inhibit the absorption or the effect of yohimbine. The secretion of insulin with the intake of carbohydrates directly inhibits the lipolysis, through which yohimbine exerts its action, whether combined with exercises or not.

Yohimbine stimulates the fat burning mainly through the sympathetic nervous system, which is responsible for the "active" body mode. Insulin inhibits the action of the sympathetic nervous system and it respectively blocks the mechanism of fat burning. 

Insulin is the primary regulator of lipolysis and the lowering of its levels is needed for the optimal stimulation of the sympathetic nervous system. The short explanation is that the carbohydrates intake suppresses the activation of the sympathetic nervous system and consequently the process of burning fat. 

At low levels of insulin, yohimbine stimulates the sympathetic nervous system to the maximum by enhancing lipolysis.

Do not forget that the sympathetic nervous system is associated with increased energy levels, increased stamina, improved concentration, and mental attitude. These factors improve the quality of training, which is an indirect cause for more burned fat.

How Does Yohimbine Affect the Pancreas Function

It has been found that yohimbine, when to be added to food, enhances insulin secretion by the pancreatic cells when the process is induced by glucose administration. However, the same effect does not occur when yohimbine is taken on an empty stomach.

In vitro studies on pancreatic cells have reached the conclusion that the alpha-adrenergic receptors stimulate adrenaline to suppress the secretion of insulin with the intake of carbohydrates.

The same results are confirmed by tests on dogs. The use of 3.3 mg of yohimbine HCL/kg on dogs not only stimulates insulin secretion but also enhances the release and the pancreatic hormone somatostatin and glucagon. 

The mechanism is associated first with the blocking of the α2 receptor, as another possible mechanism associated with the central nervous system is also mentioned.

At this stage studies in rats have shown promising results, according to which the intake of 2.5 mg Yohimbine HCL/kg of bodyweight enhances the serum insulin levels and the blood flow to the pancreas and in diabetic animals. 

Such an effect does not occur in healthy rats. It is interesting to note that yohimbine also increases the plasma levels of the hormone leptin, which is directly related to carbohydrate metabolism.

How to Take Yohimbine HCL and Yohimbe Bark

Dosages of 0.2mg/kg bodyweight have been successfully used to increase fat burning without significant implications on cardiovascular parameters like heart rate and blood pressure. 

This results in a dosage of:

  • 14 mg for a 150lb person;
  • 18 mg for a 200lb person;
  • 22 mg for a 250lb person.

Supplementation is most effective between meals or during short term fasting. If the target is a maximum fat loss, then it is advisable to consume yohimbine on an empty stomach, preferably in the morning after getting up before training. The evening intake is not recommended.

When the intake on an empty stomach is impossible, then you can resort to an unproven hypothesis, according to which yohimbine can cause lipolysis, if taken with a few fats and proteins, because carbohydrates and large amounts of proteins induce the insulin secretion.

Possible Side Effects

Yohimbe has been linked to reports of severe side effects including irregular or rapid heartbeat, kidney failure, seizure, heart attack, and others.

When taken by mouth in typical doses, yohimbe and the ingredient yohimbine can cause stomach upset, excitation, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting.

What to Do According to Our Diet

In high-fat diets, there should not be a case with the intake of yohimbine. If you are on a high-protein diet, you are recommended to take yohimbine on an empty stomach or at meals with less protein.

In the case of a high-carb diet, the intake on an empty stomach is mandatory. When the diet is evenly balanced, consumers have more opportunities because yohimbine could be taken on an empty stomach or with meals with little carbohydrates or without any.

If the objective is improving the insulin secretion, then it is recommended that yohimbine is taken with food, rich in carbohydrates.

In Conclusion

Yohimbe bark and Yohimbine are the two popular forms of this supplement, which you will encounter in the market. 

While both substances have the same properties –the effect of the bark is attributed mainly to yohimbine, and there is this popular idea is that bark extract is suitable for combating erectile dysfunction and increasing libido.

Yohimbe bark is unfortunately not suitable for most individuals and that is why people choose yohimbine HCL. 

It is preferred mostly for losing weight and reducing body fat. It is also recommended for erectile problems. Depending on what your goals are, you can select the appropriate option.

The rankings and product reviews on brainsandgainz.com are curated to save you time by aggregating the best reviewed products from the most reputable companies. We may receive a commission if you buy something using a link on this page.

 written by 

Brains $ Gainz

🥩carnivore

°minimalist fitness and simple living
°synthesizing health-related knowledge
°on a path to slow living ¬ slow food ¬ slow training